Evolution provides integrated mail, addressbook and calendaring functionality to users of the GNOME desktop. (GPL)
Linux - FreeBSD
Geary is a new email reader for GNOME designed to let you read your email quickly and effortlessly. Its interface is based on conversations, so you can easily read an entire discussion without having to click from message to message. (LGPL)
Linux
Kontact is a personal information manager and groupware software suite for KDE. (GPL)
Linux - FreeBSD
Boost your productivity and send better email with Mailspring, the best mail client for Mac, Linux, and Windows! Mailspring is a new version of Nylas Mail maintained by one of the original authors. (GPL)
Linux - Windows - macOS
N1 is an open-source mail client built on the modern web with Electron, React, and Flux. It is designed to be extensible, so it's easy to create new experiences and workflows around email. (GPL)
Cross-platform
Sylpheed is a simple, lightweight but featureful, and easy-to-use e-mail client (mailer, MUA). (GPL)
Linux - FreeBSD - Windows - macOS
Mozilla Thunderbird is a free, open source, cross-platform e-mail and news client developed by the Mozilla Foundation. (MPL)
Linux - FreeBSD - Windows - macOS
9 applications